Mastiff Dogs for Adoption

266 adoptable dogs from shelters and rescues across the US. Showing 181–210 of 266 below.

About adopting a Mastiff

"Mastiff" on a shelter listing is a broad label. It can mean an English Mastiff, a Bullmastiff, a Neapolitan, a Cane Corso, or simply a very large dog with a heavy head and loose lips whose background nobody knows. Shelter staff assign it based on what a dog looks like at intake, so the word describes a body type more than a pedigree.

What the label tends to predict is size and a calm, watchful manner. Many mastiff-type dogs are quiet in the house, slow to react, and deeply attached to their people. Puppies under this label grow fast and stay clumsy for a long stretch, so early training pays off. Adults are often already past the wild stage and settle into a routine quickly.

What the label cannot tell you is how a particular dog feels about strangers, other dogs, or being left alone. Guarding instincts run through several of the breeds grouped here and show up differently in each individual. Drool, snoring, and a big food bill come with most of them. Hip and joint concerns, bloat, and heat sensitivity are things to ask the shelter and your veterinarian about. Ask the shelter or rescue what this dog has lived through and what training he has had so far, because that matters more than the word on the card.

266 Mastiff dogs available — page 7 of 9

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Photo of PR 58 Waffles, adoptable Mastiff in Glen Allen, Virginia

PR 58 Waffles

Mastiff MaleLargeYoung

The Henrico Police Animal Shelter is accessible by appointment only. Animals available for adoption can be viewed online at petfinder.com or adoptapet…

Henrico Police Animal Shelter • Glen Allen, VA

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Photo of Kyro, adoptable Mastiff in Sacramento, California

Kyro

Mastiff MaleLarge4 years

09/09/26 doggie day out: Briefly walked by 4-6 year old kids, was friendly but uninterested Happy, friendly, affectionate. Definitely the type to foll…

City of Sacramento Animal Care Services • Sacramento, CA

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Photo of Khal Drogo, adoptable Mastiff in Sacramento, California

Khal Drogo

Mastiff MaleLarge1 year

Khal has participated in shelter playgroups and may enjoy a compatible canine friend in his new home. He's also sharing his shelter suite with a frien…

Sacramento County Animal Care and Regulation • Sacramento, CA

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Photo of Macy, adoptable Mastiff in Moreno Valley, California

Macy

Mastiff FemaleSmall0 years

Macy loves toys and treats* Macy is a sweet puppy* Macy did well on her temperament test with a male Mastiff mix**if adopted, a sponsor will pay for a…

Moreno Valley Animal Shelter • Moreno Valley, CA

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Photo of Lion, adoptable Mastiff in Moreno Valley, California

Lion

Mastiff MaleSmall0 years

Lion knows sit* Lion loves attention* Lion takes treats gently* Lion did well on his temperament test with a female Mastiff mix**if adopted, a sponsor…

Moreno Valley Animal Shelter • Moreno Valley, CA

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Photo of Sega, adoptable Mastiff in Denver, Colorado

Sega

Mastiff Female2 years

This big baby is Sega! She is sweet, gentle and has a sensitive side. She can be nervous around new people and in new situations so any kids in the ho…

Denver Animal Shelter • Denver, CO

Photo of Norman, adoptable Mastiff in Chambersburg, Pennsylvania

Norman

Mastiff MaleX-Large0 years

Meet Norman, a handsome five-month-old Mastiff Mix with a heart of gold and a personality larger than life! You might hear us call him Captain Chaos o…

Mastiffs to Mutts Rescue • Chambersburg, PA

Photo of Theo, adoptable Mastiff in Phoenix, Arizona

Theo

Mastiff MaleLargeBaby

Theo is 8 weeks old and quite possibly the happiest puppy you’ll ever meet! This chunky little boy is always ready to play, make new friends, and soak…

Adopt A Dog Rescue • Phoenix, AZ

Photo of Franny, adoptable Mastiff in Oakland Park, Florida

Franny

Mastiff FemaleX-Large0 years

She is appx. 3 months old and weighs 15 pounds. She is expected to be over 60lbs when geown. Our adoption center & Spay Clinic is open by appointment …

Animal Aid, Inc. • Oakland Park, FL

Photo of Brownie, adoptable Mastiff in Visalia, California

Brownie

Mastiff Male0 years

BROWNIE | A25587810 months old • Mastiff Mix • 83 lbsBrownie is FRIENDS WITH EVERYONE! This big, happy guy loves people, loves snacks, and seems to th…

Tulare County Animal Control • Visalia, CA

Photo of Conan, adoptable Mastiff in Irvine, California

Conan

Mastiff MaleLarge2 years

Hi, I’m Conan — your classic blocky-headed lovebug with a marshmallow heart. I know I look like a tough guy, but I’m actually a sensitive soul. It tak…

Irvine Animal Care Center • Irvine, CA

Adopting a Mastiff — FAQ

Is a Mastiff a good family dog?

Many mastiff-type dogs are gentle and patient with their own family, and their calm nature suits a quiet home. Their size means a wagging tail or a friendly lean can knock over a toddler, so supervision matters. Early socialization and clear house rules help a young dog grow into a steady adult.

How much exercise does a Mastiff need?

Less than most people expect. A couple of steady walks and some time to sniff around a yard satisfy most adults. Puppies should not be run hard or taken on long hikes while their joints are still developing. Mental work, like short training sessions, tires them out just as well.

Why do so many Mastiffs end up in shelters?

Size is the most common reason. A dog that seemed manageable as a puppy becomes expensive to feed, hard to house in a rental, and difficult to move. Some families also underestimate the drool and shedding. Very few are surrendered for aggression, and many arrive already house trained and mellow.

How do I adopt a Mastiff?

Open any dog's profile to see the shelter or rescue caring for them, then use the adoption link or contact details to apply directly with that organization. Every Dog's Chance simply gathers listings in one place so they're easier to find.

Are Mastiff dogs a good fit for first-time adopters?

Many Mastiff dogs — especially adult dogs who are already house-trained — can be a great match for first-time owners. Each dog's profile and the shelter or rescue caring for them can tell you about that dog's individual energy level, training, and personality before you apply.

How much does it cost to adopt a Mastiff?

Adoption fees vary by shelter and rescue, but typically include spay/neuter, vaccinations, and a health check. Open any dog's profile and contact the organization directly for their current fee and what it covers.

Are Mastiff dogs good with children or other pets?

It depends on the individual dog more than the breed alone. The shelter or rescue caring for each dog can tell you about their history with kids, cats, and other dogs. Many organizations offer meet-and-greets to make sure the match is right for everyone before you commit.

Can I foster a Mastiff instead of adopting?

Many shelters and rescues offer a foster program, sometimes with a foster-to-adopt path. Fostering a Mastiff gets them out of a kennel and into a calm home, which is a great way to see if the match feels right before committing. Ask the organization on any dog's profile whether fostering is an option.

What should I expect in the first weeks after adopting a Mastiff?

Most dogs have a brief adjustment period — a few days to a couple of weeks — as they settle into a new home. A consistent routine, a comfortable place to rest, and patience make the transition easier for both of you. The shelter or rescue can tell you what to expect from the specific dog you're adopting.