Mastiff Dogs for Adoption

266 adoptable dogs from shelters and rescues across the US. Showing 151–180 of 266 below.

About adopting a Mastiff

"Mastiff" on a shelter listing is a broad label. It can mean an English Mastiff, a Bullmastiff, a Neapolitan, a Cane Corso, or simply a very large dog with a heavy head and loose lips whose background nobody knows. Shelter staff assign it based on what a dog looks like at intake, so the word describes a body type more than a pedigree.

What the label tends to predict is size and a calm, watchful manner. Many mastiff-type dogs are quiet in the house, slow to react, and deeply attached to their people. Puppies under this label grow fast and stay clumsy for a long stretch, so early training pays off. Adults are often already past the wild stage and settle into a routine quickly.

What the label cannot tell you is how a particular dog feels about strangers, other dogs, or being left alone. Guarding instincts run through several of the breeds grouped here and show up differently in each individual. Drool, snoring, and a big food bill come with most of them. Hip and joint concerns, bloat, and heat sensitivity are things to ask the shelter and your veterinarian about. Ask the shelter or rescue what this dog has lived through and what training he has had so far, because that matters more than the word on the card.

266 Mastiff dogs available — page 6 of 9

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Photo of Bailey, adoptable Mastiff in Savannah, Missouri

Bailey

Mastiff FemaleLarge3 years

Hi, I'm Bailey. Like most dogs at M'Shoogys, I was found running around loose in Platte City. No one ever came to claim me so now I'm one of the many …

M'Shoogy's Famous Emergency Animal Rescue • Savannah, MO

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Photo of Morty, adoptable Mastiff in Palo Alto, California

Morty

Mastiff MaleLarge1 year

Morty is an energetic and affectionate dog who is full of curiosity and zest for life! With his boundless energy and love for adventure, he's always r…

Palo Alto Animal Services • Palo Alto, CA

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Photo of Angus, adoptable Mastiff in Pensacola, Florida

Angus

Mastiff MaleX-Large4 years

This is our big baby Angus. He is a solid 135 pound Mastiff, which are by nature, gentle, loyal, and protective dogs. Angus is all that and a bag of c…

Animal Allies Florida • Pensacola, FL

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Photo of Frank, adoptable Mastiff in Savannah, Missouri

Frank

Mastiff MaleX-Large5 years

Meet Frank, a strong and energetic young fellow who is ready to find his forever home. Frank is a protective and independent dog, but don't let that f…

M'Shoogy's Famous Emergency Animal Rescue • Savannah, MO

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Photo of Nova, adoptable Mastiff in Omaha, Nebraska

Nova

Mastiff FemaleLargeYoung

Nova is a mixed-breed puppy born February 4, 2024, with a personality that’s equal parts sweet, sassy, and adventurous. She approaches life with confi…

Bullies-N-Beyond ResQ Inc • Omaha, NE

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Photo of Presley, adoptable Mastiff in Jackson, Mississippi

Presley

Mastiff FemaleMedium2 years

Sweet girl, friendly, playful, even tempered, enjoys being outside, and is ready for her next adventure! She likes water and being in a playgroup.

Animal Rescue Fund of MS • Jackson, MS

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Photo of Nala, adoptable Mastiff in Blacksburg, South Carolina

Nala

Mastiff FemaleLarge5 years

Meet Nala! Breed: mastiff/lab mix. Age: est 4 years, est birthdate 1/22/2021 Weight: approx 65ish lbs. Training: leash, crate and housetrained. She al…

Mercy Rescue Haven • Blacksburg, SC

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Photo of Mouse, adoptable Mastiff in Riverside, California

Mouse

Mastiff FemaleSmall0 years

Riverside County Animal Control - Riverside Shelter • Riverside, CA

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Photo of Sampson, adoptable Mastiff in Clyde, North Carolina

Sampson

Mastiff MaleLarge5 years

Meet Sampson, the tall, lanky goofball who is pretty sure he’s a baby giraffe in a dog suit. At 5 years old, this maybe-Mastiff mix is all legs, all h…

Haywood County Animal Shelter • Clyde, NC

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Photo of Nessie, adoptable Mastiff in Riverside, California

Nessie

Mastiff FemaleSmall0 years

Riverside County Animal Control - Riverside Shelter • Riverside, CA

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Photo of Rosco, adoptable Mastiff in Long Beach, California

Rosco

Mastiff MaleLarge1 year

INFO: This pet is currently being fostered but is available for adoption! Please email petadopt@longbeach.gov for more information.

Long Beach Animal Care Services • Long Beach, CA

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Photo of Cafe, adoptable Mastiff in Albuquerque, New Mexico

Cafe

Mastiff MaleMedium2 years

Meet Cafe! Looking for a big, cheerful sidekick with a heart to match? Meet Cafe, a 2-year-old, 75-pound Mastiff mix whose happy personality has made …

Albuquerque Animal Services - Westside • Albuquerque, NM

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Photo of Jamison, adoptable Mastiff in Fort Pierce, Florida

Jamison

Mastiff MaleLargeYoung

Please Call directly For an appointment! 571 NE 44th St. NW corner of Prospect (44th) and 6thOakland Park, FL 33334 Our phone number is 754-223-5378E-…

Rescue Adoption Inc. • Fort Pierce, FL

Adopting a Mastiff — FAQ

Is a Mastiff a good family dog?

Many mastiff-type dogs are gentle and patient with their own family, and their calm nature suits a quiet home. Their size means a wagging tail or a friendly lean can knock over a toddler, so supervision matters. Early socialization and clear house rules help a young dog grow into a steady adult.

How much exercise does a Mastiff need?

Less than most people expect. A couple of steady walks and some time to sniff around a yard satisfy most adults. Puppies should not be run hard or taken on long hikes while their joints are still developing. Mental work, like short training sessions, tires them out just as well.

Why do so many Mastiffs end up in shelters?

Size is the most common reason. A dog that seemed manageable as a puppy becomes expensive to feed, hard to house in a rental, and difficult to move. Some families also underestimate the drool and shedding. Very few are surrendered for aggression, and many arrive already house trained and mellow.

How do I adopt a Mastiff?

Open any dog's profile to see the shelter or rescue caring for them, then use the adoption link or contact details to apply directly with that organization. Every Dog's Chance simply gathers listings in one place so they're easier to find.

Are Mastiff dogs a good fit for first-time adopters?

Many Mastiff dogs — especially adult dogs who are already house-trained — can be a great match for first-time owners. Each dog's profile and the shelter or rescue caring for them can tell you about that dog's individual energy level, training, and personality before you apply.

How much does it cost to adopt a Mastiff?

Adoption fees vary by shelter and rescue, but typically include spay/neuter, vaccinations, and a health check. Open any dog's profile and contact the organization directly for their current fee and what it covers.

Are Mastiff dogs good with children or other pets?

It depends on the individual dog more than the breed alone. The shelter or rescue caring for each dog can tell you about their history with kids, cats, and other dogs. Many organizations offer meet-and-greets to make sure the match is right for everyone before you commit.

Can I foster a Mastiff instead of adopting?

Many shelters and rescues offer a foster program, sometimes with a foster-to-adopt path. Fostering a Mastiff gets them out of a kennel and into a calm home, which is a great way to see if the match feels right before committing. Ask the organization on any dog's profile whether fostering is an option.

What should I expect in the first weeks after adopting a Mastiff?

Most dogs have a brief adjustment period — a few days to a couple of weeks — as they settle into a new home. A consistent routine, a comfortable place to rest, and patience make the transition easier for both of you. The shelter or rescue can tell you what to expect from the specific dog you're adopting.